Fetal hemoglobin (HbF) is the major modifier for thalassemia severity. HbF is modulated mainly by three major quantitative trait loci (QTL). One of the SNPs in these loci is HBG2. Thirty seven patients with beta thalassemia major from pediatric hematology unit of Minia University hospital, Minia were investigated by a panel of primers and probes using Polymorphism strip assay (β-Thal Modifier StripAssay) Vienna lab. In our study the frequency of wild CC genotypes were 31 patients (83.8%), 5 patients (13.5%) were heterozygous CT and only 1 patient (2.7%) was homozygous TT. We also reveled significant association between HBG2 and Hb F level in beta thalassemia major patients in Minia governorate children.
El Sherif, A., Salah, K., Hegazi, A., & Elfateh, R. (2020). The prevalence of HBG2 polymorphism among Beta Thalassemia major Children in El Minia Governorate and its correlations with HbF level.. Minia Journal of Medical Research, 31(3), 24-26. doi: 10.21608/mjmr.2022.219854
MLA
Ahmad A. El Sherif; Khaled M. Salah; Aliaa M. Monir Hegazi; Rania W. Mostafa Elfateh. "The prevalence of HBG2 polymorphism among Beta Thalassemia major Children in El Minia Governorate and its correlations with HbF level.". Minia Journal of Medical Research, 31, 3, 2020, 24-26. doi: 10.21608/mjmr.2022.219854
HARVARD
El Sherif, A., Salah, K., Hegazi, A., Elfateh, R. (2020). 'The prevalence of HBG2 polymorphism among Beta Thalassemia major Children in El Minia Governorate and its correlations with HbF level.', Minia Journal of Medical Research, 31(3), pp. 24-26. doi: 10.21608/mjmr.2022.219854
VANCOUVER
El Sherif, A., Salah, K., Hegazi, A., Elfateh, R. The prevalence of HBG2 polymorphism among Beta Thalassemia major Children in El Minia Governorate and its correlations with HbF level.. Minia Journal of Medical Research, 2020; 31(3): 24-26. doi: 10.21608/mjmr.2022.219854
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