Thalassemias are the commonest inherited hemoglobinopathies in the world. Approximately 68,000 children are born with various thalassemia syndromes each year. β-Thalassemia represents a major public health problem in Egypt. beta thalassemia. It is caused by reduced or absent synthesis of beta globin chains. Aim of the work: Determine frequencies & association of HLA DQB1 alleles in βthalassemia major patients. Patients: forty-five unrelated randomly selected β-thalassemia major patients, and forty-five unrelated randomly selected healthy individuals, composed the control group with age matched to patients of group I. Study procedure: Routine lab investigations & HLA DQB1 genotyping by real time PCR. The Kit were supplied by DNA-TECHNOLOGY (catalog no.334-1), Russia. Conclusion: HLA DQB1*0601 give significance importance as an etiological risk factor for β-thalassemia major; HLA DQB1*0302 give significance importance as a preventive risk factor for βthalassemia major.
Kamal Eldin, A., Abd El Naem, ,., Elsayed, M., & Zaki Mahmoud, N. (2020). The Associations between HLA DQB1 different Alleles and β-thalassemia Major. Minia Journal of Medical Research, 31(4), 197-200. doi: 10.21608/mjmr.2022.217932
MLA
Amel M. Kamal Eldin; ,Emad A. Abd El Naem; Mostafa A. Elsayed; Nada O. Zaki Mahmoud. "The Associations between HLA DQB1 different Alleles and β-thalassemia Major". Minia Journal of Medical Research, 31, 4, 2020, 197-200. doi: 10.21608/mjmr.2022.217932
HARVARD
Kamal Eldin, A., Abd El Naem, ,., Elsayed, M., Zaki Mahmoud, N. (2020). 'The Associations between HLA DQB1 different Alleles and β-thalassemia Major', Minia Journal of Medical Research, 31(4), pp. 197-200. doi: 10.21608/mjmr.2022.217932
VANCOUVER
Kamal Eldin, A., Abd El Naem, ,., Elsayed, M., Zaki Mahmoud, N. The Associations between HLA DQB1 different Alleles and β-thalassemia Major. Minia Journal of Medical Research, 2020; 31(4): 197-200. doi: 10.21608/mjmr.2022.217932
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