Expression of Tyrosinase, Tyrp1 and Tyrp2 in vitiligo

Document Type : Original Article

Authors

Department of Dermatology, faculty of medicine, Minia University, Minia, Egypt.

Abstract

Vitiligo, an acquired idiopathic pigmentary disorder of skin and hair, is characterized by wellcircumscribed asymptomatic white cutaneous macules and patches, where selective destruction of 
functioning melanocytes. Tyrosinase (TYR) gene family, a major determinant of human pigmentary 
differences, consists of three members of genes, which produce three proteins called tyrosinase related 
proteins (Tyrps).
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Main Subjects