Magnetic resonance imaging of multiple sclerosis

Abd El-Ghany, Hosny S.; Abdel Gawad, Enas A.; Esmaeel, Mohamed M.; Moneer, Mahmoud M.; Fathy, Alaa W.; Elshafei, Ahmed M.; Othman, Mohamed F.; Mohamed, Asmaa A.; Rabie, Mahmoud E.

doi:10.21608/mjmr.2022.217922

Magnetic resonance imaging of multiple sclerosis

Document Type : Original Article

Authors

¹ Department of Radiology, El-Minia Faculty of medicine, El-Minia- Egypt

² Department of Radiology, El-Minia Faculty of medicine, El-Minia- Egypt.

³ Department of Neurology and Psychiatry, El-Minia Faculty of medicine, El-Minia- Egypt.

⁴ Department of Ophthalmology, El-Minia Faculty of Medicine

10.21608/mjmr.2022.217922

Abstract

Background: Magnetic resonance imaging (MRI) has an important role in early diagnosis of
MS. Multiple sclerosis (MS) is a demyelinating disease of the central nervous system.
Patients and Methods: forty patients clinically diagnosed to have MS according to
McDonald criteria were included and referred to department of radio-diagnosis, Faculty of
Medicine, Minia University. Imaging was performed on a 1.5T Philips MR system using
double inversion recovery (DIR), fluid attenuated inversion recovery (FLAIR), T2-weighted,
T1-weighted and susceptibility-weighted imaging (SWI) sequences with the parameters
including field of view (FOV), matrix, slice thickness and voxel size. They were done after
the approval of ethical committee of our institution. Data analysis was performed using the
SPSS version 20 and p-value as well as comparative study were gained. Results: The
detection rate of white matter lesions in T2 was (80%); while for grey matter lesions was
(12%). In FLAIR sequence, we found that; the detection rate of white matter lesions was
(97%); while for grey matter lesions was (26%). As regarding DIR sequence, the detection
rate of white matter lesions was (93%); while for grey matter lesions was (95%).Comparative
study between serial MRI sequences (T2,FLAIR and DIR) revealed; significant increase in
detected number of grey matter lesions; in DIR-MRI sequence (p < 0.0001). In SWI, a central
vein sign was detected in 97 lesions (66 in periventricular lesions and 31 in subcortical
lesions). Conclusion: From this study we concluded that new imaging modalities of MRI as
regarding DIR and SWI are a valuable MRI sequences in imaging of multiple sclerosis; thus,
we recommend adding DIR and SWI sequences in routine MR protocols for MS patients.

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