Is Lidocaine better than Magnesium Sulfate as an adjuvant with propofol in Colonoscopy?

Document Type : Original Article

Authors

1 Department of Anesthesia, El-Minia Faculty of Medicine

2 Department of Anesthesia, El-Minia Faculty of Medicin

Abstract

Background: Colonoscopy is one of the most commonly performed outpatient procedures 
throughout the world as a screening, diagnostic, and therapeutic tool. propofol is the most 
common drug used for sedation during endoscopy either alone or in combination with another 
agent. Patients and Methods: A total of 90 patients of both gender aged between 18 and 70 
years with American Society of Anesthesiologists grade I and II patients scheduled to 
undergo colonoscopy, under sedation were included in the study. Patients were randomly 
allocated into 3 equal groups each containing 30 patient. Group (L) received 1.5 mg/ kg of 
lidocaine IV before induction by propofol and continuous infusion of lidocaine 4 mg kg/ h 
after induction, group (M) received50 mg/ kg of magnesium sulphate before induction by 
propofol and continuous infusion of magnesium 8 mg/ kg/h after induction and group (O) as 
control group received normal saline 0.9% Sodium Chloride. Results: There was a significant 
difference in intraoperative hemodynamic stability, total amount of propofol, post procedural 
pain and analgesic demand, and patient between three groups. Conclusion: we concluded that 
lidocaine infusion by dose 1.5 mg/kg loading and 4 mg/kg/ h as maintenance is more effective 
than magnesium sulfate by dose 50 mg/kg loading and 8 mg/kg/ h maintenance in decreasing 
total amount of propofol, post procedural pain and analgesic demand, and improving patient 
satisfaction in patient undergoing colonoscopy under sedation with propofol.

Keywords

Minia Journal of Medical Research
Volume 31, Issue 4
October 2020
Pages 95-100

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