Role of CD58 in minimal residual disease detection of ALL patients at South Egypt Cancer Institute

Mohammed, Mona I.; El- Ashmawy, Hossam El-Sayed A.; Hashim, Alaa M.; Sayed, Douaa M.

doi:10.21608/mjmr.2022.217115

Role of CD58 in minimal residual disease detection of ALL patients at South Egypt Cancer Institute

Document Type : Original Article

Authors

¹ Department of Clinical pathology, General Hospital, Minia, Egypt

² Department of Clinical pathology, Faculty of Medicine, Al-Azhar University, Egypt

³ Department of Clinical pathology, South Egypt Cancer Institute, Assiut University, Egypt

10.21608/mjmr.2022.217115

Abstract

Objective: To determine the role of CD58 marker in Minimal Residual Disease (MRD)
monitoring in B-cell Precursor ALL patients at South Egypt Cancer Institute (SECI).
Methodology: This study was carried out in Department of Clinical pathology, South Egypt
Cancer Institute, from October 2017 to December 2019. We used SECI Flowcytometry lab 4
color acute leukemia panel for diagnosis, then we studied the role of CD58 in detection of
MRD by applied it twice; at diagnosis and at day21 (post induction). Results: 50 patients
were included in our study with acute lymphoblastic leukemia (ALL) who underwent CBC,
BM aspiration and immunophenotyping. The mean age was 9.14±5.53 years. It included 31
(62%) males and 19 (38%) females. MRD by CD58 was positive in 18 (36%) of patients
while was negative in 32 (64%). CD58 show sensitivity of 100%, specificity of 97%, positive
predictive value of 94.4% and negative predictive value of 100% whereas the overall
diagnostic accuracy of CD58 in MRD detection in ALL patients was calculated to be 98%.
Conclusion: CD58 showed a high sensitivity to assess MRD in ALL patients, so its use to
detect MRD in ALL is very useful.

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