Systemic immune-inflammation index (SII) as a predictor of TIMI flow in STEMI patients undergoing primary PCI

Articles in Press

Document Type : Original Article

Authors

1 Cardiology Department , Faculty of Medicine, Minia University, Minia

2 Department of clinical pathology, faculty of medicine, minia university ,Minia, Egypt.

3 Professor and Head of Cardiology Department-Faculty of Medicine - Minia University

Abstract

Background: Atherosclerosis is an inflammatory process that leads to formation of an atheromatous plaque which is formed of huge number of inflammatory cells together with enormous lipid core that are all surrounded by a thin fibrous cap.

Objectives: This study aim was to investigate the value of systemic immune-inflammation index (SII) as a predictor of TIMI flow in acute ST Elevation Myocardial Infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI).

Methods: From June 2024 to March 2025, the current study included 389 patients who presented within 24 hours of chest pain onset and diagnosed as "STEMI". All patients were managed by pPCI. Assessment of post revascularization TIMI flow was done as grades of perfusion (TIMI flow grade).

Results: Group 1 (TIMI 0,1,2) post pPCI had higher values of SII, TLC, Neutrophils and platelets than group 2 (normal TIMI flow) (1704.7±1229) vs. (1088±961), P =<0.001, (12.7±5.1) vs. (10.5±4.4), P =<0.001, (9508±4368) vs. (7495±3989), P =<0.001 and (301.9±91) vs. (281.9±81.9), P = 0.02 respectively.

SII index at an optimal cut off value >1011.55 can predict patients with abnormal TIMI flow post pPCI with 72% sensitivity and 65% specificity with total accuracy = 67%

Conclusion: The SII can strongly predict abnormal TIMI flow in STEMI patients undergoing pPCI.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 02 July 2025

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