Demographic and Clinical Data in a Cohort of ITP Cases at Minia Pediatric Hematology Unit.

Abdel Hafez, Asmaa Hosni; Mahmoud, Ayman Ahmed; Khamis, Sara Said Abdelazim; Ali, Suzan Mohamed

doi:10.21608/mjmr.2025.394071.1988

Demographic and Clinical Data in a Cohort of ITP Cases at Minia Pediatric Hematology Unit.

Articles in Press

Document Type : Original Article

Authors

¹ Pediatric department, Faculity of medicine, Minia university, El Minia

² Clinical pathology department, Faculty of medicine, Minia Univerisity

³ pediatric department Faculty of Medicine, Minia University, Egypt

⁴ Department of Pediatrics, Faculty of Medicine, Minia University, El-Minia, Egypt

10.21608/mjmr.2025.394071.1988

Abstract

Primary immune thrombocytopenia (ITP) is a common bleeding disorder in children, characterized by low platelet counts.About 25% develop persistent or chronic ITP. The pathophysiology involves increased platelet destruction and impaired platelet production. Demographic factors like age, gender,consanguinity,and nutritional status can influence the incidence and clinical course of ITP. Understanding these factors is crucial for optimizing management strategies.

Aim:In this study we aimed to assess demographic and clinical data in a cohort of ITP cases at Minia Pediatric Hematology Unit,providing valuable insights into regional differences and aligning findings with international data.

Methods: The study was conducted at Minia University Children Hospital's Pediatric department from March 2024 to April 2025,focusing on 60 children aged 2-18 years old with or newly diagnosed ITP. The children were either admitted in the inpatient ward or followed up in the outpatient clinic of Pediatric Hematology and Oncology Unit. The study also included 60 children who were apparently healthy and matched the previous group. Full history, demographic, and clinical data were assessed.

Results: this study showed that the mean age at ITP cases was 6.1±3.3 years with a slight male predominance. There was no statistically significant difference in age, gender, BMI,or vital signs between ITP patients and controls. A higher proportion of ITP cases had consanguineous parents compared to controls,but not statistically significant. Newly diagnosed ITP cases was the most frequent type.

Conclusion: Pediatric ITP cases at Minia Pediatric Hematology Unit were mostly at school aged. Newly diagnosed was the most common type followed chronic and persistent.

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