Angiopoietin-like protein 8 as a Potential Predictor of MAFLD and its Relation to Levels of 25-hydroxy Vitamin D3

Meshref, Dalia Abdelrahman; Mostafa, Alaa M; Abdel Fattah, Asmaa S.M.; Abdullah, Noha

doi:10.21608/mjmr.2025.382762.1958

Angiopoietin-like protein 8 as a Potential Predictor of MAFLD and its Relation to Levels of 25-hydroxy Vitamin D3

Articles in Press

Document Type : Original Article

Authors

¹ Department of Clinical and Chemical Pathology, Faculty of Medicine, Minia University, Minia, Egypt.

² Lecturer Hepatology Gastroenterology and Endemic Medicine Minia university

³ internal medicine department,faculty of medicine,Minia university

⁴ Clinical pathology department, Minia University Hospital, Faculty of Medicine, Minia, Egypt

10.21608/mjmr.2025.382762.1958

Abstract

This study aims to investigate ANGPTL8 and Vitamin D level in MAFLD subjects and healthy control and to assess their relationship as well as to detect the relation between their levels and degree of fibrosis and other clinical parameters.Methods: The current study included 120 subjects involved 80 patients having MAFLD and 40 healthy control subjects, MAFLD was diagnosed by combination between abdominal ultrasound findings and the relevant diagnostic criteria established by the International Expert Consensus on MAFLD. The participants were assessed for liver function tests, renal function, lipid profile, serum ANGPTL8 and 25(OH) D level.

Results

Levels of 25(OH)D were significantly lower in MAFLD patients when compared to control group (P < 0.001). Interestingly vitamin D level was lower in patients with fibrosis compared to patients without fibrosis (P < 0.001). ANGPTL8 levels were higher in MAFLD patients when compared to control group (P < 0.001). Moreover, ANGPTL8 levels was higher in patients with fibrosis compared to patients without fibrosis (P < 0.001). Circulating ANGPTL8 was increased in patients with vitamin D deficiency.

Conclusion

This study highlights an notable interplay between vitamin D and ANGPTL8 in the context of MAFLD and hepatic fibrosis. The marked reduction in vitamin D, particularly in cases with hepatic fibrosis, suggests a potential role in disease progression.

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