Evaluation of plasminogen activator inhibitor 1 as a potential biomarker of prethrombotic state in obesity

Georgy, Christine Hany; Osman, Ashraf M M.; Moness, Hend M; Ismail, Doaa Elzaeem; Kamel, Asmaa Khalf

doi:10.21608/mjmr.2025.375925.1934

Evaluation of plasminogen activator inhibitor 1 as a potential biomarker of prethrombotic state in obesity

Articles in Press

Document Type : Original Article

Authors

¹ Clinical pathology department, Minia university

² Clinical Pathology, Faculty of Medicine , Minia University

³ Clinical Pathology Department, Faculty of Medicine, Minia University, Minia, Egypt

⁴ Clinical Pathology Department , Faculty of Medicine , Minia University ,Egypt

⁵ Clinical pathology department, Faculty of medicine, Minia University

10.21608/mjmr.2025.375925.1934

Abstract

Background

Obesity is a complex metabolic disorder associated with a prothrombotic state, increasing the risk of cardiovascular diseases. Plasminogen Activator Inhibitor-1 (PAI-1) plays a key role in inhibiting fibrinolysis, leading to impaired clot breakdown and contributing to thrombotic risk.

Aim

This study aims to evaluate the serum levels of PAI-1 in obese individuals and assess their correlation with obesity severity according to degree of body mass index (BMI) and thrombotic markers.

Methods

The present study was carried out at the Clinical Pathology Department, Faculty of Medicine, Minia University, Minia, Egypt, it was conducted on 90 subjects. The study included 60 obese patients (BMI > 30) divided into two subgroups: Group Ia (BMI > 35) and Group Ib (BMI < 35), and 30 healthy subjects with matched age and sex. Laboratory investigations included complete blood count, coagulation parameters (INR, APTT, D-dimer), and serum levels of PAI-1 measured by ELISA.

Results

Obese patients showed significantly higher levels of PAI-1 compared to controls (p < 0.05). A positive correlation was found between PAI-1 and BMI (r = 0.396, p < 0.05). Additionally, PAI-1 levels were positively correlated with platelet count (r = 0.327, p = 0.011), suggesting a potential link between obesity and a prethrombotic state.

Conclusion

This study highlights the association between obesity and increased thrombotic risk, as indicated by elevated levels of PAI-1. These findings suggest that PAI-1 could serve as a potential biomarker for prethrombotic states in obese individuals, emphasizing its role in assessing thrombotic risk in this population.

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Main Subjects