Serum fatty acid binding protein as apredictor of traumatic brain injury outcome

Kamal, Hany; Youssef, Ibrahim Abbas; Mohamed, Rehab; El Zaeem, Tamer; Abdel-rahman, Wegdan

doi:10.21608/mjmr.2025.359677.1901

Serum fatty acid binding protein as apredictor of traumatic brain injury outcome

Articles in Press

Document Type : Original Article

Authors

¹ Anesthesiology and Intensive Care Department, Minia University.

² Anesthesiology & Intensive care department, Faculty of Medicine, El-Minia University, Egypt.

³ Anesthesiology and Intensive Care Department, Minya University, Minya, Egypt.

⁴ Radiology Department, Faculty of Medicine, Minia University, Minia, Egypt

⁵ Anesthesiology and Intensive Care Department, Minia University, Egypt.

10.21608/mjmr.2025.359677.1901

Abstract

Background: Permanent impairment and reliance caused by traumatic brain injuries (TBIs) constitute a significant public health concern. The diagnostic gold standard, computed tomography (CT), is not without its hazards, including radiation exposure and expensive expenditures. Recent research has suggested that heart-type fatty acid-binding protein (H-FABP) may serve as a biomarker for cardiac and brain damage. The usefulness of H-FABP in predicting neurological outcomes after moderate TBI is examined in this study.

Methods: Minia University Hospital performed a prospective controlled experiment on 30 adults suffering from traumatic brain injury. The ATLS criteria were used to evaluate the patients. The patient's serum fatty acid binding protein, a biomarker for cardiac injury, was examined at various points between admission and the third day of intensive care following the accident. At various points up until their release from the intensive care unit, patients were evaluated for outcome using the Glasgow coma scale.

Results: The mean HFABP increased significantly after 24 hours, then declined after 72 hours, but remained significantly higher than the admission day. There were significant differences between the admission value and subsequent values (p value 0.05). When comparing GCS at admission and discharge between improved and deteriorated cases, the results showed a significant difference (p value <0.001), with improved cases having significantly higher means of GCS than deteriorated cases. Conclusion: HFBP is an accurate indicator for prognosis in TBI patients.

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