The hemodynamic effects of ketofol versus fentanyl-propofol in neurosurgical operations

Articles in Press

Document Type : Original Article

Authors

1 Department of Anesthesia and Intensive care, Faculty of medicine, Minia University

2 Anesthesia and ICU department, Minia University

Abstract

Background : Anesthesia for neurosurgical patients aims to maintain stable hemodynamics, cerebral perfusion pressure (CPP), appropriate cerebral oxygenation, and relaxed brain to facilitate surgical procedures.

Objectives: evaluate the relative merits of fentanyl-propofol and ketofol as neurosurgical induction and maintenance anesthetics.

Study design: The study was prospective, randomized, and double-blind, and forty adults took part.

Method: xFor elective neurosurgery procedures, 40 patients were randomly assigned to one of two groups and given general anesthesia. For induction and maintenance of anesthesia, one group received a mixture of ketamine and propofol, while the other group received a combination of fentanyl and propofol. Both groups had their intraoperative hemodynamic stability monitored.

Results: ketofol (Group A) combination produced a significantly greater stability in pulse rate and in mean arterial pressure as compared to fentanyl (Group B) after induction of anesthesia (P=0.037) , (P=0.023) respectively and intraoperatively.

Conclusion: Improved hemodynamic stability during induction and maintenance anesthesia without a rise in intracranial pressure is achieved with ketofol combination compared to fentanyl-propofol.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 27 November 2024

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