The potential harmful effect of cyclophosphamide on the placenta in rats

Articles in Press

Document Type : Original Article

Authors

1 Department of medical pharmacology, faculty of medicine , Minia university

2 Medical pharmacology department, Faculty of Medicine, Minya University

3 Department of medical pharmacology, faculty of medicine, minia University, minia,Egypt.

4 Department of Medical Pharmacology , faculty of medicine, Minia university

5 department of histology, faculty of medicine, Minia University, Minia, Egypt

6 Department of medical pharmacology, Faculty of medicine, Minia university, Minia, Egypt

Abstract

Abstract:

Background & Aim: Placental insufficiency is one of the hazardous complications that may occur during pregnancy leading to adverse pregnancy outcomes. Cyclophosphamide (CYC) is one of the chemotherapeutic drugs that can be used for the treatment of many cancers and autoimmune diseases. One of its indication is the treatment of SLE in pregnant women. The current study aimed to investigate the effect of CYC on the placenta.

Materials and methods: twelve female Wister albino rats were randomly divided into 2 experimental groups. Group 1: control pregnant group; Group 2: pregnant rats received CYC (20 mg/kg, i.p). Placental malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant capacity (TAC), NADP oxidase 4 (NOX4) and caspase-3 were measured. Histological changes were also evaluated.

Key findings: CYC showed a significant decrease in placental TAC but a significant increase in placental MDA, NOX4, and caspase-3.

Conclusion: The current study revealed that CYC has toxic effects on placenta confirmed by inducing oxidative stress, inflammation and apoptosis in placental tissue.

Keywords

Main Subjects

Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 26 August 2024

Files

Share

How to cite

Statistics