Effect of hepatic ischemia reperfusion on testicular tissue in rats

Articles in Press

Document Type : Original Article

Authors

1 Medical Pharmacology Department, Faculty of Medicine, Minya university

2 Medical Pharmacology Department, Faculty of Medicine, Minya University

3 Medical pharmacology Department, Faculty of Medicine, Minya University

4 Pathology Department, Faculty of Medicine, Minya University.

5 Medical Pharmacology Department, Faculty of Medicine, Minia University

Abstract

Background: Hepatic ischemia reperfusion (HIR) injury is a major cause of liver damage occurring in many surgical circumstances such as liver transplantation resulting in tissue injury and remote organ affection which are dangerous medical conditions that carry poor prognosis to the patients and need to be managed and prevented efficiently. There are no clear data addressing the effect of HIR injury on testicular tissue in rats. This study aimed to evaluate the effect of HIR injury on testicular tissue with the explanation of possible underlying causes.

Methods: Rats were allocated into 2 groups; group 1: Sham (received carboxymethyl cellulose) for 5 days, groups 2: HIR group. Rats were sacrificed after 30 minutes of ischemia and 60 minutes of reperfusion. The effect of HIR on rat testes was evaluated by serum testosterone and histopathological assessment.

Results: No significant differences were revealed in HIR group in comparison to the sham group.

Conclusion: There is no significant affection of testes after HIR.

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Minia Journal of Medical Research

Articles in Press, Accepted Manuscript
Available Online from 01 July 2024

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