Comparison of hemodynamics changes after infusion of Dexmedetomidine versus Midazolam as a premedication in pediatric patients undergoing lower abdominal surgery

Mahmoud, Maha Salah Mohammed; Talaat, Ibrahim; Yakoub, George Abdel-Shaheed

doi:10.21608/mjmr.2024.254588.1562

Comparison of hemodynamics changes after infusion of Dexmedetomidine versus Midazolam as a premedication in pediatric patients undergoing lower abdominal surgery

Articles in Press

Document Type : Original Article

Authors

¹ Anesthesiology and Intensive Care Department, Faculty of Medicine, Minia University, Minia, 61519, Egypt.

² Anesthesia and ICU department, Minia University

³ Anesthesia and intensive care department ,Minia University, Minia university hospital,Minia, Egypt

10.21608/mjmr.2024.254588.1562

Abstract

Background:

The administration of anesthesia and the surgical procedure can potentially have adverse impacts on hemodynamics. Premedication, midazolam and dexmedetomidine, was utilized in this study to mitigate the stress response. The administration of midazolam resulted in hemodynamic effects. This study showed that dexmedetomidine can reduce the requirement for anesthesia and mitigate the body's response to stressful events during surgical procedures.

Patients and methods:

This study comprised a total of sixty patients who underwent general anesthesia for lower abdomen surgery at Minia University Hospital. The experiment was conducted using a prospective and randomized study design. Group M was administered intravenous midazolam, whereas group D received intravenous dexmedetomidine. The participants were assigned to one of these groups in a random manner. Both groups underwent a conventional anesthetic treatment. We assessed the heart rate and blood pressure at different time intervals.

Results:

Comparing the baseline parameters of the two groups showed no statistically significant disparity. There was a noticeable change in heart rate between the two groups after the premedication infusion. The heart rates of Group M and Group D exhibited a significant difference (p<0.05). Following administration of the medicine, group M exhibited significantly elevated blood pressures compared to group D, with a p-value of less than 0.05, indicating statistical significance. There was a distinct disparity between the two groups regarding the alteration in the initial measurements of heart rate and blood pressure.

Conclusion:

The use of dexmedetomidine resulted in a significant enhancement in hemodynamic stability and effectiveness.

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