COVID-19 IN Children

Objective: Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a pandemic in March 2020, affecting millions of people worldwide. However, COVID-19 in pediatric patients represents 1–5% of all cases, and the risk for developing severe disease and critical illness is much lower in children with COVID-19 than in adults. The clinical severity of the infection varies from a simple cold to severe acute respiratory syndrome (ARDS) or even death. Multisystem inflammatory syndrome in children (MIS-C), a possible complication of COVID-19, has been described as a hyperinflammatory condition with multiorgan involvement similar to that in Kawasaki disease or toxic shock syndrome in children with evidence of SARS-CoV-2 infection. Methods: 148 children were selected for our study. The demographic data, clinical manifestation, and laboratory measurements were also collected. Results : There was a statistically significant difference between positive covid-19 cases and negative cases as regarding inflammatory markers (CRP , LDH, D.Dimer and ferritin)


Introduction
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease has since spread worldwide, leading to an ongoing pandemic. [1][2][3] . The clinical severity of the infection varies from a simple cold to severe acute respiratory syndrome (ARDS) or even death [2] . The infection is reported to be rarely seen in childhood and commonly affects ≥15 years old; however, the number of pediatric COVID-19 cases has increased rapidly with the global spread of the infection [4] .

statistical analysis:
The analysis of the data was carried out using the IBM SPSS 26.0 statistical package software (IBM; Armonk, New York, USA). Normality of the data was tested using the Kolmogorov-Smirnov tests. Data were expressed as median, interquartile ranges (IQR) for quantitative measures, in addition to both number and percentage for categorized data. Mann-Whitney U test for non-parametric data were used for comparison between two independent group, The Chi-square test or Fisher's exact test were used to compare categorical variables. A pvalue less than 0.05 was considered significant.

Result
Clinical and laboratory data of the studies groups were tabulated and statistically analyzed Result of the study are shown in the present tables as following:

Discussion
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) first appeared in Wuhan, China, and was announced as a pandemic in March 2020 [6] . The clinical severity of the infection varies from a simple cold to severe acute respiratory syndrome (ARDS) or even death [2] . According to demographic data of our cases, ages of our children ranged from 1month to 18 years with median age 6 month (2.13 -17.3). This finding suggests that all ages of childhood were susceptible to covid-19 with non significant difference between positive and negative PCR cases or clinical severity as in table (1) and this agreed with Dong, Mo et al., [7] who show that Children of all ages were susceptible to COVID-19 .
Median time from the onset of symptoms prior to hospitalization was 5 days without significant difference between positive or negative pediatric covid-19 cases and that was similar to previous reports Cheung, Zachariah et al., [8] .
Our study demonstrate in table (1) that there is a significant difference between positive and negative pediatric covid19 cases as regarding sex with p value 0.049 and 57% of positive cases are male while 43% are female , agree with Lu, Zhang et al., [9] who reported that majority of the infected children in China were reported to be males . The cause of male predominance is unclear but partly it may be due to outdoor playing activities of male children as compared to girls leading to increased risk of exposure.
Our study show variation in clinical presentation of cases as fever 98.2% ,cough 75% ,shortness of breath 69.6% ,vomiting 25% , diarrhea 23.2% ,convulsion 23.2% as in table (2) this agree with Dong, Mo et al., [10] and 55.4% need mechanical ventilation and respiratory support without significant difference between positive and negative cases and this agree with Fan, Beitler et al., [11] In our study Table (3) show significant increase in inflammatory markers LDH ,Ferritin and D. Dimer in covid-19 cases with p value 0.0001 , 0.004, 0.014 respectively and this agree with Hernández, Nan et al., [12] , who report increase in inflammatory markers with covid-19. also table (3) show significant leucopenia in pediatric covid-19 cases with significant p value .001 and this agree with Rahimzadeh, Ekrami Noghabi et al., [13] who present 9 pediatric cases of COVID-19 … Three cases had leukopenia . and also agree with Carlotti, Carvalho et al., [14] who report a leukopenia in 26.3% of patients among a series of 171 pediatric cases of COVID-19. as table (3). but disagree with Bari, Ch et al., [15] who found that there was no significant leukopenia in pediatric cases of COVID-19.